The Austria international left the pitch in the first half of the game at Anfield and subsequently underwent a scan to assess the extent of her injury.
Dr Amelia Woodhouse, LFC Women club doctor, said: “Marie’s scan results confirmed an injury to her anterior cruciate ligament, and she will now begin a period of rehabilitation with the support of everyone at the club.
“She will also have a surgical review in the coming days.”
Höbinger joined the Reds from FC Zurich Frauen in the summer of 2023 and signed a new contract in January this year after establishing herself as a key part of the squad.
Head coach Gareth Taylor added: “Of course we’re all devastated for Marie and football can be a cruel game at times.
“But everyone here at Melwood – our medical staff, the coaching and backroom team and Marie’s teammates – will all be right behind her and giving her our full support during her rehabilitation programme.
“It’s a tough road back but we will be with her every step of the way and helping her in any way we can.”
