The Reds discovered their eight opponents for the first stage of the competition proper during UEFA proceedings in Monaco on Thursday afternoon.
It will see the Premier League champions play host to Real Madrid, Atletico Madrid, PSV Eindhoven and Qarabag at Anfield, and travel to face Internazionale, Eintracht Frankfurt, Marseille and Galatasaray.
Shortly after the draw had taken place, Slot told Liverpoolfc.com: “I think the first thing to say is that like last season, it is a very challenging draw, but we knew that it would be because in the Champions League, especially with the new format, there is no such thing as an easy draw.
“But what is also clear is that this is a very exciting draw, full of big games both home and away.
“To be able to welcome Real Madrid to Anfield again is something special. Last season’s game was of course a memorable one – and I expect the same this time around. That is, I am sure, a fixture that the whole world will be looking at.
“On a personal note, it is always nice to play against a Dutch team in PSV Eindhoven, a team that won the league title two years in a row. The same goes for Galatasaray, who have won three in a row in Turkey, and for Qarabag, the champions of Azerbaijan.
“And to also play against sides of the calibre of Inter Milan, Atletico Madrid, Eintracht Frankfurt and Marseille shows the strength of this competition.
“None of our league-phase games will be straightforward, that is clear, but I am sure our supporters will be looking forward to all of the Anfield games and to all of the away fixtures, which will all be played in big stadiums with fanatical and passionate fans.
“They will be excited and so are we. We have a very busy schedule coming up, both domestically and in Europe, but we are excited and ready for the challenges ahead.”
Fixture dates and kick-off times will be confirmed on Liverpoolfc.com by Saturday at the latest.