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Check out the companies making headlines before the bell: Oracle — The software giant tumbled more than 12% after reporting fiscal second-quarter revenue that missed analyst expectations. Analysts across Wall Street raced to lower their price targets. Adobe — Shares fell slightly after the software company issued lackluster guidance for fiscal year 2026. Adobe sees earnings per share in a range of $23.30 to $23.50. Analysts polled by FactSet expected a forecast for $23.38 per share. Eli Lilly — A late-stage trial showed the company’s next-generation obesity drug, retatrutide, delivered what appears to be the highest weight loss yet while…

Celsopupo | Istock | Getty ImagesZealand Pharma on Thursday outlined an ambitious five-year strategy for its anti-obesity portfolio Thursday, spotlighting how growing competition from smaller players is tightening the race for market leaders Novo Nordisk and Eli Lilly as more of these medicines near market entry.The new strategy, “Metabolic Frontier 2030,” comes as Zealand shares have dropped 29% year to date as investors are betting the market will fragment, with fewer singular winners than they were 18 months ago at the peak of the weight loss drug frenzy.Ahead of its Capital Markets Day on Thursday, the Danish drugmaker said it now…

Miniseries | E+ | Getty ImagesThe U.S. Department of the Treasury and IRS this week shared details about the health savings account updates enacted via President Donald Trump’s “big beautiful bill.”The notice covers the legislation’s new tax benefits for HSAs, including wider eligibility via high-deductible health plans, or HDHPs. Participants must have an eligible HDHP to make HSA contributions. HSAs offer three tax benefits: an upfront deduction for contributions, tax-free growth and tax-free withdrawals for qualified medical expenses.   “These changes expand HSA eligibility, which allows more people to save and to pay for healthcare costs through tax-free HSAs,” the IRS…

The mobile-messaging application WhatsApp is displayed on an Apple iPhoneBrent Lewin | Bloomberg | Getty ImagesFor investment firms of the ultra rich, WhatsApp is a one-stop shop for everything from vetting deals to finding the best surgeons. Sam Nallen Copley, an investment advisor at a London-based family office, runs a 970-person WhatsApp group for single-family offices and has seen it all, from verifying credentials to finding co-investors to selling multimillion-dollar collections of dinosaur bones and Pokémon cards.”If I need something at any time of day, I can message nearly 1,000 people about a new bitcoin fund or ask who’s the…

With the Africa Cup of Nations kicking off on December 21, Sky Sports News’ Yoseph Kiflie takes a look at the storylines to watch from every group…Group AMorocco being favourites, but also as hosts, the tournament serves as a warm-up to the 2030 World Cup that they’ll be co-hosting with Spain and Portugal. The team has been building towards success over the past decade with investment in youth pathways culminating in that semi-final run at Qatar, but they might be without captain Achraf Hakimi for the early stages after his horrible ankle injury against Bayern Munich. Image: Achraf Hakimi could…

Jyoti Bansal, co-founder and CEO of Harness, speaks at the company’s Unscripted conference in London on Sept. 25, 2025.HarnessAlmost nine years ago, Jyoti Bansal sold AppDynamics to Cisco for $3.7 billion just as the software startup was set to go public. Bansal’s latest venture, Harness, is now worth substantially more than that, after raking in $200 million in fresh capital at a $5.5 billion valuation in a funding round led by Goldman Sachs.Harness’ technology helps companies manage and monitor code that’s produced with the help of artificial intelligence, making sure it doesn’t break, create security vulnerabilities or trigger cost overruns.…

Josko Gvardiol has said Manchester City’s win over Real Madrid at the Bernabeu should act as a warning to the rest of Europe that they’re capable of beating anyone this season.City came from behind to win 2-1 in Madrid on Wednesday to move up to fourth in the Champions League table.Away from Europe, Pep Guardiola’s side are trying to chase down Arsenal at the top of the Premier League.Josko Gvardiol hopes Manchester City’s win at Real Madrid is a warning to their rivals. GettyAnd Gvardiol believes it’s a good sign ahead of the second half of the campaign that City have…

The Eli Lilly logo appears on the company’s office in San Diego, California, U.S., Nov. 21, 2025.Mike Blake | ReutersEli Lilly on Thursday said its next-generation obesity drug delivered what appears to be the highest weight loss yet in a late-stage trial while reducing knee arthritis pain, clearing the first of several upcoming studies on the weekly injection. The highest dose of the drug helped patients with obesity and a type of knee arthritis lose an average of 23.7% of their body weight at 68 weeks, when analyzing all participants, including those who discontinued treatment. When evaluating only patients who stayed on…

Mohamed Salah will feel like he is letting down 50 million people in Egypt by having his role reduced at Liverpool, according to ex-Egypt striker Mido, who believes the forward must move to the Saudi Pro League.In an exclusive interview with Sky Sports News, the ex-Tottenham striker, who won the 2006 Africa Cup of Nations with Egypt, reflected on his own career to explain Salah’s Anfield predicament and also believes Jamie Carragher was wrong to criticise Salah. ‘I understand Salah’s situation'”I’ve been in this situation before. When the Liverpool game is on, all of Egypt are there in front of…

As central banks make different decisions on rates this week and next, their economies all show one thing, according to Deutsche Bank: Global reflation is back. “Something’s cooking. In contrast to US rates, the rest of the world looks far more interesting,” George Saravelos, global head of FX Research at Deutsche Bank, said in a note issued ahead of the announcement. Reflation means an attempt to lift the economy after weak growth, typically by lowering rates, buying government bonds, and cutting taxes to encourage spending. A “sharp re-pricing was underway” in Australia, Saravelos said, as the market now expects a rate…