Mohamed Salah is away at the Africa Cup of Nations, as are Tottenham midfielders Yves Bissouma and Pape Matar Sarr.
The hosts have no fresh injury concerns following their defeat by Nottingham Forest last time out.
They do, however, remain without Radu Dragusin, Dejan Kulusevski, James Maddison, Dominic Solanke, Kota Takai and Destiny Udogie.
Spurs boss Thomas Frank said: “Everyone is doing fine. Last game, it’s the same players available. No-one new is available in the squad.”
Like Liverpool, Frank’s side come into this game having not played in midweek, which has allowed for greater time on the training pitch.
“It’s been nice to finally have a full training week. That helps. I’ve said a few times, we have a few good players out with a lot of goals and assists in them,” Frank continued.
“A full week definitely helps a lot. I would be very surprised if we don’t have the energy. If you play in the Premier League and Europe at the same time, it is a massive physical and mental load – but no excuses, that’s what we want.”
Last match
Nottingham Forest 3-0 Tottenham (December 14): Vicario, Porro, Romero, Van de Ven, Spence, Bentancur, Gray, Simons, Kudus, Kolo Muani, Richarlison.
Liverpool 2-0 Brighton & Hove Albion (December 13): Alisson, Gomez, Konate, Van Dijk, Kerkez, Gravenberch, Jones, Mac Allister, Szoboszlai, Wirtz, Ekitike.
